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Toxicity

SB Stephen W. Booth
TE Toby A. Eyre
JW John Whittaker
LC Leticia Campo
LW Lai Mun Wang
ES Elizabeth Soilleux
DR Daniel Royston
GR Gabrielle Rees
MK Murali Kesavan
CH Catherine Hildyard
FK Farasat Kazmi
NT Nick La Thangue
DK David Kerr
MM Mark R. Middleton
GC Graham P. Collins
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Adverse events were categorised and graded according to the National Comprehensive Cancer Network Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Patients were assessed during screening and on cycle 2 day 15 by slit lamp and fundoscopy assessment. Triplicate electrocardiograms (ECGs) were performed at screening and all safety visits. Dosing was interrupted for development of QTc > 470 milliseconds until resolution to < 450 milliseconds and discontinued if QTc was increased by ≥60 milliseconds or to > 500 milliseconds. AEs are presented according to number and percentage of patients by worst grade experienced, and by the number and percentage of administered cycles affected to give an indication of the longitudinal persistence of toxicity over time and to facilitate comparison with published data from the escalation portion of the study [20, 23].

Copyright and License information: The Author(s) ©2021
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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