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Thermal hyperalgesia was tested on a Hot-Plate Analgesia Meter (Columbus Instruments, Columbus, OH, USA) set at 53 °C. The animals were placed individually on the preheated hot-plate surface and exposed to heat until nociceptive reaction was registered. The test was discontinued if withdrawal response was not observed for 30 s. The pain threshold was detected as latency to hind paw withdrawal or licking. Measurements were carried out 2, 4, and 24 h after the injection of carrageenan.
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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