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The Cytoscape (version 3.7.2) app ClueGO (version 2.5.5) [25] was employed for ontology and pathway analysis of lists of differentially expressed genes (DEGs). A list of 300 DEGs with the top 150 most positive log2 and 150 most negative log2 values was used to query gene ontology (GO) databases (UniProt-GOA_08.01.2020 for Biological process, Cellular component, and Molecular function) and Reactome databases (Pathway_08.01.2020 and Reactions_08.01.2020). See S1–S6 Figs in S1 File and S2 Table.
Copyright and License information: ©2021 Mazzarino et al
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