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2.5. Synthesis of 2-Isopropyl-2-oxazoline (iPrOx)
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The monomer was synthesized using a modified Witte-Seelinger cyclocondensation.43,44 Isobutyronitrile (90 mL, 1 mol) was mixed with 72 mL (1.2 mol) of ethanolamine in the presence of 4.4 g (0.02 mol) of zinc acetate dihydrate as the catalyst at 130 °C for 24 h. The product was dissolved in DCM, followed by extraction with water until the pH of the aqueous phase was neutral. It was dried over calcium hydride and distilled in a nitrogen atmosphere to yield an anhydrous product.
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