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Wellcome trust case control consortium (WTCCC)

DG D. S. Goodin
PK P. Khankhanian
PG P. A. Gourraud
NV N. Vince
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The WTCCC cohort included 18,872 controls and 11,376 cases with MS. The patients enrolled in the multinational WTCCC were of European or European-American ancestry. This cohort has been described previously [12–14]. For 380 controls and 232 cases the SNP data was incomplete. All of the SNP data was post-quality control [12]. Of the cases, the average age-of-onset was 32.3 years, 72.9% were women, and the mean Extended Disability Status Score (EDSS) was 3.9 [12]. The large majority (89%) of the cases had a relapsing–remitting onset [12]. The diagnosis of clinically definite MS was based upon international criteria [37–39]. Control subjects were composed of healthy individuals with European ancestry [12]. The protocol was approved by the ethical committees or institutional review boards at each of the participating centers. Informed consent was obtained from each study participant. The WTCCC granted data access for this study.

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