Statistics

Subject characteristics are summarised as mean±SD and other results as mean±SEM. Data were tested for normality and compared using either one-way ANOVA or the Mann-Whitney U test, as appropriate. Ethnicity distribution was assessed by the chi-squared test for categorical variables. Pearson correlation coefficients were used to identify linear relationships between continuous variables. Independent predictors of LV remodelling were identified by multivariate linear regression. All tests were 2-tailed and differences were considered significant at p<0.05. Bonferroni correction was applied for multiple comparisons.

Measurement variability for 3D data and 2D strain was assessed in fifteen randomly selected studies using intra-class correlation coefficients. Intraclass correlation coefficients demonstrated inter-observer variability of r = 0.84 for 3D EF, r = 0.73 for GLS. Intra-observer variability was r = 0.75 for 3D EF, r = 0.79 for GLS.