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Integrated metabolomic and proteomic analysis

AM Aubrey N. Michi
BY Bryan G. Yipp
AD Antoine Dufour
FL Fernando Lopes
DP David Proud
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Integrated pathway analysis was performed using MetaboAnalyst 5.0. Gene lists and compound lists were entered as fold change relative to matched timepoint noninfected cells. Official gene symbol was selected for gene list ID type and compound name selected for compound ID type. The integration occurred in the universe defined by metabolic pathways, which includes pathways containing both metabolites and metabolic genes. Enrichment analysis was performed by hypergeometric test, and topology measured degree centrality. We used combined queries as the integration method.

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