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Metascape

HS Hui Sun
LM Li Ma
JC Jie Chen
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We further explored the biological significance of the DEGs by analysing the enriched functions and pathways of the DEGs using Metascape (http://metascape.org). 16 We used ‘custom analysis’ in Metascape to explore Gene Ontology (GO) terms, including the biological process (BP), cellular component (CC), and molecular function (MF) categories, and also identified enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, based on Metascape. Significant enrichment was indicated by a minimum overlap of 3, P-value cut-off of 0.01, and minimum enrichment of 1.5. The most significant term within a cluster was chosen to represent the cluster.

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