Severity Symptom Index and Stress Response

The rationale that guided this choice was not determined by a specific symptomatology (i.e., anxiety, depression, insomnia, and all possible combinations between these symptoms); rather, a quantitative criterion was chosen that is consistent with the perspective of allostatic load. Thus, positivity or negativity to PHQ-9, GAD-7, and ISI clinical cutoffs was used to identify four severity symptoms profiles: all indexes negative (Profile_0), equal or above cutoffs either in one (Profile_1), two (Profile_2), or all of the three scales (Profile_3). We evaluated how overall IES-R distress and its three components are distributed over those profiles.