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4.2.2. Proteomic Datasets

HJ Heather Jackson
SM Stephanie Menikou
SH Shea Hamilton
AM Andrew McArdle
CS Chisato Shimizu
RG Rachel Galassini
HH Honglei Huang
JK Jihoon Kim
AT Adriana Tremoulet
AT Adam Thorne
RF Roman Fischer
MJ Marien I. de Jonge
TK Taco Kuijpers
VW Victoria Wright
JB Jane C. Burns
CC Climent Casals-Pascual
JH Jethro Herberg
ML Mike Levin
MK Myrsini Kaforou
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The proteomic discovery dataset was generated from plasma samples using LC–MS/MS. Full details of the experimental protocol are in the Supplementary Text. The proteomic validation dataset was generated from serum samples using the SomaScan (SomoLogic, Boulder, CO, USA) aptamer-based platform [20]. Prior to pre-processing, 867 proteins were measured in the discovery dataset (LC–MS/MS) and 1300 in the validation dataset (SomaScan). Samples in the proteomic validation dataset were split across three plates with KD, DB, DV and HC samples present on each plate in relative proportions.

Copyright and License information:  ©2021 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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