CAST.APP/PS1 Transgenic Mouse Model

The CAST.APP/PS1 transgenic mouse line, which expresses human APP^swe and PS1^dE9, was created in the Howell lab colony at The Jackson Laboratory by backcrossing for at least seven generations the APP/PS1 transgenes from C57BL/6J (B6) to CAST.¹¹ Brain samples (forebrain and hindbrain) were extracted from six female CAST.APP/PS1 and six female CAST (WT) littermate control mice at 8 months of age. Mice were anesthetized with ketamine/xylazine prior to tissue harvest.