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2.4.7. Magnetic resonance imaging (MRI)
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An MRI scan is conducted on a GE 3T at baseline and at 12 months to examine changes in our primary outcome measure of hippocampal volume. MRI data are processed using the Neuroreader 42 neuroimaging software to extract normalized region brain volumes. Neuoreader is an FDA‐cleared brain volumetric software package that has validated that hippocampal volume remains the best single volumetric predictor of conversion from MCI to AD. 43
Additional exploratory outcome scans for future analyses include: 15‐direction DTI, resting‐state functional MRI, and 3D ASL.
Copyright and License information: ©2021 The Authors. published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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