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HG Haoyu Gao
XS Xiaogang Sun
YL Yanxiang Liu
SL Shenghua Liang
BZ Bowen Zhang
LW Luchen Wang
JR Jie Ren
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We searched for the datasets including AAD patients in the GEO database (https://www.ncbi.nlm.nih.gov/geo/). The inclusion criteria were as follows: (I) samples in the dataset were collected from the aorta; (II) the samples included AAD patients and healthy controls; (III) the dataset was based on human gene expression profiles. The exclusion criteria included that the raw data of microarray data or the counts data of high-throughput sequencing data were not available. Three datasets, GSE52093, GSE98770 and GSE153434 that met the criteria were included in this study. The platform of the GSE52093 dataset was GPL10558 (Illumina HumanHT-12 V4.0 expression beadchip). The gene expression profiling data of the GSE98770 dataset were obtained via mRNA and miRNA microarrays, and the platform of the mRNA microarrays was GPL14550 (Agilent-028004 SurePrint G3 Human GE 8 × 60K Microarray); these datasets were analyzed in this study. Gene expression profiling data in the GSE153434 dataset were obtained by high-throughput sequencing, and the platform was GPL20795 (HiSeq X Ten).

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