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Spared Nerve Injury Model of Neuropathic Pain
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Neuropathic pain was induced by spared nerve injury (SNI) in rats. To produce SNI, the tibial and common peroneal nerves were tightly ligated with 5–0 silk, followed by transection and removal of 3–5 mm nerve segments, as previously described (Decosterd and Woolf, 2000; Wen et al., 2007). Caution was taken not to touch the sural nerve during surgery. In this model, neuropathic pain was measured in the sural nerve territory.
Copyright and License information: ©2021 Tao, Luo, Zhang, Hershey, Esteller and Ji.
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