The Oxford Levels of Evidence as produced by the Oxford Centre for Evidence-Based Medicine were used to categorize methodological quality (http://www.cebm.net/ocebm-level-of-evidence/). This tool classifies systematic randomized clinical trials and inception cohort studies as Level II evidence, cohort studies or control arm of randomized trials as Level III evidence, and case series or case–control studies or poor-quality prognostic cohort studies as Level IV evidence.
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