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To assess the effect of combining miransertib and sirolimus, the combination index (CI) was calculated using the Chou-Talalay method (26). The CI was obtained using CompuSyn (http://www.combosyn.com/) according to their instructions. A synergistic effect was determined when the calculated CI at a Fa50 (effect level of 50%) was <1.0.
Copyright and License information: ©2021 Rivera-Soto, Yu, Dittmer and Damania
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