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DE% is determined from the percentile ratio of the area under the curve (AUC) of the dissolution data to the AUC of 100% release between time zero to the end of dissolution [59]. It was obtained using the equation below. OriginPro 2017 software was used to calculate the area under the curve.

where t is the time, y is the percentage of drug dissolved at time t, and 0ty×dt is the area under the curve.

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