2.3. Probiotics and Synbiotics

The yeast Sac. boulardii probiotic Enterol^® (Biocodex, Gentilly, France) contains in each capsule 4.5 × 10⁹ colony forming units (CFU) of the Sac. boulardii strain CNCM I-745. Dicoflor^® (Bayer Sp. z o.o., Warszawa, Poland) contains 6 × 10⁹ CFU of Lacticaseibacillus rhamnosus GG ATCC^© 53103 per capsule. BioGaia^®, (InfectoPharm Arzneimittel und Consilium GmbH, Heppenheim, Germany) contains 10⁸ CFU Limosilactobacillus reuteri DSM 17938 per 5 drops. Lakcid^® (Biomed-Lublin S.A., Lublin, Poland) contains a total of 2 × 10⁹ CFUs as mixture of the Lacticaseibacillus rhamnosus strains E/N (40%), Oxy (20%) and Pen (40%), [39]. The multi strain synbiotic A (Multilac^® Synbiotic, Vivatrex GmbH, Aachen, Germany) contains in each capsule 9.00 × 10⁸ Lactococcus lactis Ll-23, 9.00 × 10⁸ CFUs Lactobacillus helveticus SP 27, 6.75 × 10⁸ CFUs Bifidobacterium longum Bl-05, 4.5 × 10⁸ CFUs Bifidobacterium breve Bb-03, 4.5 × 10⁸ CFUs Lacticaseibacillus rhamnosus Lr-32, 4.5 × 10⁸ CFUs Streptococcus thermophiles St-21, 2.25 × 10⁸ CFUs Lacticaseibacillus casei Lc-11, 2.25 × 10⁸ CFUs Lactiplantibacillus plantarum Lp-115, 2.25 × 10⁸ CFUs Bifidobacterium bifidum Bb-02, and 68 mg of the prebiotic fructooligosaccharides (FOS). The multi strain synbiotic B (Multilac^® Baby, Vivatrex GmbH, Aachen, Germany) is a freeze-dried powder. Each sachet contains a total of 10⁹ CFUs as a mixture of equal CFU amounts of Lactobacillus acidophilus LA-14, Lacticaseibacillus casei R0215; Lacticaseibacillus paracasei Lpc-3; Lactiplantibacillus plantarum Lp-115; Lacticaseibacillus rhamnosus GG, Ligilactobacillus salivarius Ls-33, Bifidobacterium lactis Bl-04, Bifidobacterium bifidum R0071, Bifidobacterium longum R0175 and 1.43 g of FOS.