Protocol to request
            
                Reconstruction of free energy surface (FES) from the RAM simulations
                
                
            
        
        
            
                Research article
            
            
                The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
                
            
            
            
                Cristina Olivieri et al.
            
            
                DOI: 10.7554/eLife.91506