DAVID Bioinformatics Resources 6.8 was used to analyze the parental gene functions of the differentially expressed circRNAs. Gene Ontology (GO) analysis of the parental genes was conducted based on biological processes, cellular components and molecular functions (https://www.geneontology.org/). And Kyoto Encyclopedia of Genes and Genomes (KEGG, https://www.genome.jp/kegg) was used to analyze the related biological pathways. The -log (P-value) was used as the enrichment score indicating the significance of correlation.

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