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Cell Deconvolution

JD Jiacheng Dai
YC Yu Chen
RD Rujia Dai
YJ Yi Jiang
JT Jianghua Tian
SL Sihan Liu
MX Meng Xu
ML Miao Li
JZ Jiaqi Zhou
CL Chunyu Liu
CC Chao Chen
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We used cell deconvolution to estimate cell proportion of brain cell types in ROSMAP datasets. We used R package MuSiC (Wang et al., 2019b), which utilizes cell-type specific gene expression from single-cell RNA sequencing data to characterize cell type compositions from bulk tissue RNA-seq data. In our analysis, we used single-cell RNA sequencing data from ROSMAP (Mathys et al., 2019) as reference of cell deconvolution.

Copyright and License information:  ©2021 Dai, Chen, Dai, Jiang, Tian, Liu, Xu, Li, Zhou, Liu and Chen.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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