3.1.41. 4-(5-Bromo-1H-indol-3-yl)-N-(2-chlorophenyl) pyrimidin-2-amine B4

Yield: 41%, pale yellow solid, mp 173.8–174.6 °C. ¹H NMR (400 MHz, DMSO-d₆) δ 11.94 (s, 1H), 8.74 (s, 1H), 8.41 (s, 1H), 8.36 (d, J = 2.7 Hz, 1H), 8.29 (d, J = 5.4 Hz, 1H), 7.83 (d, J = 8.3 Hz, 1H), 7.55 (d, J = 8.0 Hz, 1H), 7.43 (d, J = 7.8 Hz, 1H), 7.39 (d, J = 8.3 Hz, 1H), 7.26 (t, J = 6.8 Hz, 2H), 7.21 (d, J = 7.6 Hz, 1H). ¹³C NMR (100 MHz, DMSO-d₆) δ 162.65, 161.04, 157.64, 137.31, 136.19, 130.82, 130.15, 128.30, 128.06, 127.30, 126.98, 125.99, 125.24, 124.85, 114.29, 113.96, 113.52, 107.76. HRMS calcd for C₁₈H₁₃BrFN₄⁺ [M + H] ⁺399.0007, found 399. 0002.HPLC purity 98.97% (t_R = 15.7 min).