Biomarkers were considered as any laboratory blood test performed in the ED. A clinical scoring system was defined as any scoring system using a combination of patient characteristic with or without laboratory testing used for prognostic purpose. We did not use a single definition of sepsis in this review. Sepsis criteria changed multiple times in the previous decades and we did not want to miss any potential useful article in our initial search strategy We used 1-month mortality as outcome, which was defined as either 28 or 30-day mortality.

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