The following compounds were purchased from Bachem: SSTR2 antagonist (PRL-2915, catalog H-6056), Ex9–39 (catalog H-8740), GLP-1 (catalog H-6795), and Bombesin (catalog H-2155). Dimethyl sulfoxide (DMSO, CAS no. 67-68-5), 2-hydroxypropyl β-cyclodextrin (HPCD, catalog H107), and arginine (catalog A5131) were purchased from Sigma-Aldrich. The SSTR5 antagonist (compound B, 6-[[1-[(4-Chloro-3,5-diethoxyphenyl)methyl]-4-piperidinyl]amino]-3-pyridinecarboxylic acid; hydrochloride) was a gift from F. Hoffmann-La Roche Ltd. (22). The DPP-4i valine pyrrolidide was a gift from Novo Nordisk A/S.
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