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RI Rola Ismail
PP Peter Parbo
LM Lasse Stensvig Madsen
AH Allan K. Hansen
KH Kim V. Hansen
JS Jeppe L. Schaldemose
PK Pernille L. Kjeldsen
MS Morten G. Stokholm
HG Hanne Gottrup
SE Simon F. Eskildsen
DB David J. Brooks
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Participants were recruited from Memory/Dementia clinics in Denmark or by advertisement and were screened/assessed as previously described [15]. Our Alzheimer’s disease cases were formally diagnosed by these clinics in Denmark in accordance with the ICD-10 clinical criteria while the MCI subjects fulfilled the Petersen clinical criteria [17]—we applied no formal diagnostic rating threshold for the severity of their cognitive deficits. During the recruiting period, we ascertained a total number of 43 MCI subjects. The programme was initially designed to longitudinally investigate the inter-relationship between Aβ fibril load and levels of inflammation in MCI subjects. During the conduct of the study, 18F-Flortaucipir PET also became available to image tau tangles. The PET scans were scheduled to all be performed within 10 weeks, but for six subjects, the flortaucipir scan was performed up to 1 year later than the two other scans due to delayed tracer availability (see Additional file 1).

Copyright and License information: The Author(s) ©2020
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