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70 male SPF SD rats weighed 200 ± 20 g (10 per group) were provided by Experimental Animal Centre of Xinjiang Medical University (Urumqi, China). Animal production license number was SYXK(XIN)2016-0003 and certificate number was SCXK(XIN)2016-002. The study was approved by the Animal Ethnics Committee of the First Affiliated Hospital of Xinjiang Medical University (approval number 20180223-183). They were maintained with free access to water and food in plastic cages and kept in a 12 h light/dark cycle at a temperature of 22 ± 2°C and humidity of 45–55% in our Experimental Animal Centre.

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