Data management and quality control

Data will be recorded on paper forms at District clinics, and entered into a custom-designed online database by study staff. Chest radiographs will be read independently by two readers, including a member of the clinic and a study medical advisor. Where discrepancies are identified between the readings, a third reader will adjudicate between the first two readings. Quality control of laboratory testing will include routine structured quarterly monitoring visits by staff from the National Lung Hospital. Quality control processes are detailed in online supplementary file 1. The investigators will have access to the final trial data set. Microbiological isolates collected from study participants, and blood samples collected for biomarker testing, will be stored for use in subsequent ancillary studies.