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The effect of SMUG1 and UNG knockout on genomic lesion levels were assessed using an unpaired t-test or analysis of variance (ANOVA) on group differences, based on three samples in each group. The resulting p-values were adjusted for multiple testing according to the Holm-Šídák procedure and reported as adjusted p-values using GraphPad software (v6.07). The level of significance was set at p < 0.05. Biochemical assays were evaluated using two-tailed t-test 95% confidence level.
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