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Detection of DMI subfamilies
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From the domain-mediated PPI network, we detected DMI subfamilies, which consist of proteins sharing the same DMI. Each DMI subfamily contains at least three proteins and includes fewer members than the parent-domain family. However, DMI subfamily members may interact with different proteins, even if those proteins belong to the same DMI subfamily. Thus, we also classified DMI subfamilies with single-shared PPI partners or with multiple-shared PPI partners and investigated the biological relevance of their members.
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