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The EPM, as previously described [31], consisted on four perpendicular arms (two open and two closed) with an elevation of 40 cm off the floor. Each mouse was individually placed in the center is the platform and allowed to explore for 5 min. Exploration of center, closed arms, and open arms was tracked and recorded using ANY-maze software (www.anymaze.com). The chamber was cleaned with 10% ethanol between trials.
Copyright and License information: ©2019 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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