Pathogen-free Sprague-Dawley rats (Samtako, Korea) weighing 200–250 g were used at 7 weeks of age and housed in the laboratory animal facility of the medical college of Korea University. Rats were anesthetized for the experiment with 50 mg/kg of ketamine and 20 mg/kg of xylazine. All experimental protocols were approved by the Institutional Animal Care and Use Committee of Korea University.
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