For WBI, mice were treated with 5 Gy using an x-ray cabinet (Kimtron Polaris SC-500). For focal RT, mice were treated with 5 Gy using a conformal small-animal irradiation system (X-RAD SmaRT, PXi, North Branford, CT) outfitted with a 5 mm diameter collimator. Radiation treatment planning was performed using RTImage. Cone-beam CT images were acquired prior to RT to set the radiation isocenter on the center of the tumor.
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