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The cffDNA sequencing data were analyzed with an automated pipeline that, starting with the paternal, maternal and cffDNA BAM files, predicts the most likely haplotypes inherited by the foetus and validates the results with those determined by sequencing the trophoblast DNA obtained via chorionic villous sampling (CVS). The cffDNA analysis workflow is extensively described in Supplementary Note 3 and Figure 2.
Copyright and License information: ©2017 Macmillan Publishers Limited, part of Springer Nature.
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