Replication stage.

Conditional logistic regression (Data Supplement) was used to investigate the main effect of each SNP (assuming an additive genetic model) identified as significantly associated with cardiomyopathy in the discovery stage. Age at diagnosis of primary cancer (continuous variable), sex, chest radiation (yes/no), anthracycline dose, CVRFs (yes/no), and the SNPs of interest were included in the analysis.

We used conditional logistic regression (Data Supplement) to replicate the gene-environment (anthracycline dose) interaction effect of a SNP identified as significantly associated with anthracycline-related cardiomyopathy in the discovery stage. Age at diagnosis of primary cancer (continuous variable), sex, and chest radiation (yes/no), anthracycline dose, CVRFs (yes/no), SNP, and SNP-anthracycline interaction were included in the analysis.