Patient information and tissue specimens

This study, which complied with all relevant ethical regulations for work with human participants was conducted on a total of 367 paraffin-embedded ovarian cancer samples and four freshly collected ovarian cancer tissues that were histopathologically and clinically diagnosed at the Affiliated Guangzhou Women and Children's Hospital and Sun Yat-sen University Cancer Center. The clinical information regarding the samples is summarized in Supplementary Tables S3 and S4. All patients received standardized platinum-based chemotherapy. Platinum resistance and sensitivity refer to the time-to-relapse within 6 months or after 6 months following completion of platinum-based chemotherapy. The study protocols were approved by the Institutional Research Ethics Committee of Sun Yat-sen University Laboratory Animal Center for the use of these clinical materials for research purposes.