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Construction of a hepatoma cell differentiation trajectory
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To verify the significance of genes related to cancer differentiation trajectory, we generated a hepatoma cell differentiation trajectory using the Monocle2 R package. Using the ConsensusClusterPlus package in R, 360 HCC samples in the TCGA LIHC cohort were divided into 3 clusters based on their expression of genes related to hepatoma cell evolution. Then, Kaplan–Meier (K-M) survival curves for each cluster were generated. Correlation analysis of clinical characteristics was performed for the 3 clusters.
Copyright and License information: ©2022 Bai, Chen, Cheng, Li, Chi, Zhang, Zhang, Tang, Zhao, Ang and Zhang
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