Bioinformatic Analysis of Cadherin 2 Expression

Possible interaction between CDH2 gene expression in glioblastoma biopsies and survival were analyzed using GlioVis Data portal.¹³ The data sets TCGA_GBMLGG, REMBRANDT, and CGGA Primary were used to evaluate the mRNA level (log2) of the CDH2 gene. CGGA and TCGA_GBMLGG data sets provide data from RNA-sequencing and REMBRANDT data set from microarray. Gene expression data in glioblastoma versus other tissue or lower grade gliomas (I, II, III) were compared using the Tukey HSD (Honest Significant Difference) test. CDH2 gene expression effect on survival from the 4 data sets presented above were shown using Kaplan-Meier plots. Each plot displays the statistical analyses, the P-value and the median survival time.