2.3. Acute METH administration model

In the first part of the experiment, 24 mice were divided into four groups including control, 5, 1, and 0.25 mg/kg psilocin. In the second part of the experiment, 25 mice were divided into four groups including control, METH only, and, 1 or 0.25 mg/kg psilocin administered prior to i.p injection of METH. In the third part of the experiment, 36 mice were divided into six groups including control, 2 mg/kg TFP‐2HCl, 10 mg/kg SCH772984, METH, 2 mg/kg TFP‐2HCl and 10 mg/kg SCH772984 administered prior to i.p. injection of METH. In all three parts of the experiment, mouse activity was monitored in an open‐field for 1 h. At the end of the experimentation, mice were sacrificed and the PFC, NAc and VTA were collected. Samples were stored at −80°C until subsequent use.