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After referring the former studies, the peri-articular perineural injection group (PG) participant was located 4 deep nerve branches including saphenous nerve, infrapatellar branch of saphenous nerve (IPBSN), superomedial genicular nerve (SMGN) and superolateral genicular nerve (SLGN) by using ultrasound guidance [19, 20]. Total of 2 mL of 5% glucose was injected (25-gauge needle) around each nerve under the real-time guidance of ultrasound images (Fig. 2).

Intra-articular prolotherapy injection combined with Peri-articular perineural injection.

The intra-articular prolotherapy injection combined with Peri-articular perineural injection (I + PG) participant was treated with the combination of IG and PG.

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