2.11. Tumour microarray

Microarrays of HGSOC patient tumours are described in (28). Briefly, from ovarian cancer cases treated at the Edinburgh Cancer Centre prior to 2007, 365 high grade serous ovarian cancer cases were identified by expert pathological review. All were treated with first line platinum containing chemotherapy after primary debulking surgery. Samples of treatment naïve tumour were taken at primary surgery, fixed in formalin and embedded in paraffin. Sections were cut for immunohistochemistry (IHC) staining. Median follow up was 13.5 years (range 0.2-22.7 years). Overall survival (OS) in this cohort was defined as the interval from pathologically confirmed diagnosis to patient death. Progression free survival (PFS) was defined as the interval from pathologically confirmed diagnosis to disease progression or recurrence, respectively. Ethical approval was obtained from South East Scotland Human Annotated Bioresource (Lothian NRS Bioresource Ethics Committee reference 20/ES/0061-SR705 and SR1518). This study was carried out in accordance with the principles of the Declaration of Helsinki.