2.1. The Cancer Genome Atlas high grade serous ovarian cancer dataset

In silico analyses of RFWD3 expression were carried out using The Cancer Genome Atlas (TCGA) dataset of 489 HGSOC cases (TCGA-OV) described in (5). Median follow up was 30 months (range 0-179 months). In this cohort, overall survival was defined as the interval from initial surgical resection to the last known contact or death. Disease free survival was defined as the interval from initial surgical resection to disease progression, date of recurrence, or date of last known contact if the patient was alive and had not recurred. Analysis was performed using the cBioportal online tool (www.cbioportal.org) (23) and Graphpad Prism v9.4.1.