2.2. Instruments

APX and CLOP tablets were formulated on a manual single-punch tablet compression machine. Pharma- test® (Germany) instruments were used to perform the friability, hardness, disintegration, and dissolution tests. Copley® tapped density tester, Ohaus® electronic balance, Ohaus® loss on drying (LOD) tester, pH/orp meter, manual sieves, digital caliper, Elma® bath sonicator, and DHG- 9023A dry oven were used during formulation and analysis. Compatibility study experiments were conducted using a Bruker Fourier transform infrared (FT-IR) vacuum spectrometer, equipped with a platinum ATR unit with single reflection diamond crystal (Bruker Optik GmbH, Rosenheim, Germany), and the obtained spectra were compared using OPUS viewer software. Quantitative analysis was performed using an Agilent HPLC 1200 series with an AS thermostat (Santa Clara, USA), and UV/ VIS detector. The used column was BDS Hypersil C₁₈, (4.6*150 mm), 5 μm, thermo-scientific part # 28105–154630. PerkinElmer double beam UV/ VIS spectrometer lambda 25, sonicator, and vacuum filter pump were also used during the analysis. For stability studies, samples were kept in a climate chamber (Binder, Tuttlingen, Germany).