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Inter-cellular and internal signalings among different clusters were inferred by CellCall78. This is a toolkit that analyzes inter-cellular communication networks and internal regulatory signals by combining the expression of ligands/receptors for certain ligand–receptor (L–R) pairs. We used a pathway-activity analysis method to explore the main pathways involved in communication between clusters. Genes that were expressed in less than 10% of the cells of a certain type were excluded from this study.
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