Datasets and acquisition

All the methods were carried out in accordance with relevant standards and regulations. All the experimental protocols analyzed in this paper using GEO database have been approved by the Ethics Committee of Beijing Tiantan Hospital (KY 2020-045-02). The GEO database (https://www.ncbi.nlm.nih.gov/geo/info/datasets.html), known as GENE EXPRESSION OMNIBUS, is a gene expression database created and maintained by NCBI, the National Center for Biotechnology Information. The Series Matrix File data file of {"type":"entrez-geo","attrs":{"text":"GSE189993","term_id":"189993"}}GSE189993, annotated as {"type":"entrez-geo","attrs":{"text":"GPL16699","term_id":"16699"}}GPL16699, was downloaded from the NCBI GEO public database, and the expression profile data of 32 patients were included, including 11 cases in the normal group and 21 cases in the disease group. The Series Matrix File data file of {"type":"entrez-geo","attrs":{"text":"GSE141024","term_id":"141024"}}GSE141024 was downloaded from the NCBI GEO public database, the annotated file was {"type":"entrez-geo","attrs":{"text":"GPL16699","term_id":"16699"}}GPL16699, and the expression profile data of a total of 8 patients were included, including 4 cases in the normal group and 4 cases in the disease group. The information of dataset {"type":"entrez-geo","attrs":{"text":"GSE189993","term_id":"189993"}}GSE189993 was obtained from microsamples of the middle cerebral artery (MCA) of MMD patients (n = 21) and control patients (n = 11). The information of dataset {"type":"entrez-geo","attrs":{"text":"GSE141024","term_id":"141024"}}GSE141024 was obtained from microsamples of the middle cerebral artery (MCA) and superficial temporal artery (STA) of MMD patients (n = 4) and control patients (n = 4).