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We also employed Phenoscanner to uncover the connections of identified pQTLs with other traits. SNPs were classified as having horizontal pleiotropy when they exhibited connections with established risk factors for MN and plasma protein, encompassing metabolic traits, proteins, or clinical characteristics. For instance, the use of specific medications such as gold compounds, d-penicillamine, and bucillamine, as well as the presence of hepatitis B and liver cancer, which are considered risk factors for MN, were excluded before conducting further analysis.
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