Performance metric

Here we use the partial correlation as the performance metric, which is the correlation between the PGS and the phenotype after they have been both residualized using the covariates used in this paper, i.e., sex, age, birth date, deprivation index, and 16 PCs. To derive 95% confidence intervals for these correlations, we use Fisher’s Z-transformation. We implement this in function pcor of R package bigstatsr and use it here.