2.4. GO Enrichment Analysis of DR/RALL-Related Genes

The GO enrichment of genes was analyzed using GOATOOLS (v 0.6.10) [55]. The core ontology (OBO format) was downloaded from http://www.geneontology.org/page/download-ontology (accessed on 2 November 2020) and the gene annotation was downloaded from http://www.geneontology.org/page/download-go-annotations (accessed on 2 November 2). All mice genes were downloaded from http://genome.ucsc.edu/cgi-bin/hg (accessed on 20 April 2020). Tables as background genes. The GO terms did not propagate counts to parent terms during the performance of GO enrichment analysis. The multiple test correction method was the Bonferroni correction and the test-wise α for multiple testing was 0.5. We defined GO terms with p-values < 0.01 as significantly enriched GO terms and filtered out GO terms that were in the top three locus levels of the biological process GO tree.