BALB/c mice, aged 8–10 weeks, were purchased from Vital River Laboratory Animal Technology Co. Ltd. (Beijing). The mice were housed in the animal care facility of the Institute of Zoology, Chinese Academy of Sciences, according to the institutional guidelines for the care and use of laboratory animals. Male mice cohabited with females at a ratio of 1:1. The day when the vaginal plug was detected was recorded as the first day of pregnancy (GD1).
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