Graphpad prism 8.0 was used for drawing the diagram of mean plasma concentration-time curves. A non-compartmental method to calculate the pharmacokinetic parameters was employed through Drug and Statistics (DAS) 3.0 software (Mathematical Pharmacology Professional Committee of China, Shanghai, China). One-way ANOVA analysis was applied to compare the pharmacokinetic parameters between different groups (p < 0.05) using SPSS (version 17.0; SPSS Inc., Chicago, IL, United States). p < 0.05 is statistically significant.
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