Relative DEG lists were uploaded using the online tools Database for Annotation Visualization and Integrated Discovery (DAVID, david.ncifcrf.gov/) and STRING (https://string-db.org/), and the results of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and protein-protein interaction (PPI) analyses were obtained. Datasets with |log fold change | ≥0.2 and adjusted p < 0.05 were deemed meaningful enrichment pathways. The “Cluster Profiler” R package was used to combine gene annotation and gene expression analyses results [47]. The results are visualized in a circular plot.
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